Anti-Alpha-Synuclein antibody [2G5]

Anti-Alpha-Synuclein antibody [2G5]

• 概述

• 产品描述The synuclein family members, including ?-synuclein (also designated NACP for non-∫-Amyloid component) and ∫-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. ?-synuclein is localized to neuronal cell bodies and synapses. ?-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation ?-synuclein has been found to be upregulated, while ∫-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of ?-synuclein has been found in patients with early onset Parkinson’s disease.
• 产品名称Anti-Alpha-Synuclein antibody [2G5]
• 分子量19 kDa
• 种属反应性Human
• 验证应用WB,IP,IF
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位CytoplasmM embrane, Nucleus, Secreted
• 其它名称
  • Alpha synuclein antibody
  • Alpha-synuclein antibody
  • Alpha-synuclein, isoform NACP140 antibody
  more

• 应用

  WB: 1;100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-500

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  Fig1: Western blot analysis of α-synuclein expression in non-transfected (A) and human α-synuclein transfected (B)293T whole cell lysates.

   

  

  Fig2: Western blot analysis of α-synuclein expression in SH-SY5Y whole cell lysate.

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