Anti-NAK / TBK1 antibody [2G1]

Anti-NAK / TBK1 antibody [2G1]

• 概述

• 产品描述The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. TANK binding kinase (TBK1), also designated T2K, is a novel IKK-related kinase that has been identified in murine and human tissues. TBK1 was shown to complex with TRAF2 and TANK in the NFκB activation pathway. TBK1 shares homology with IKKα and IKKβ in the amino-terminal half, which includes the kinase domain.
• 产品名称Anti-NAK / TBK1 antibody [2G1]
• 分子量80 kDa
• 种属反应性Human, Mouse, Rat
• 验证应用WB, IP
• 抗体类型小鼠单抗
• 免疫原Synthetic peptide within Human TBK1 aa 563-577.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm.
• 其它名称
  • EC 2.7.11.1 antibody
  • FLJ11330 antibody
  • NAK antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)

•  

  

  Fig1: Western blot analysis of TBK1 expression in RAW264.7 (A), MCF7 (B) and KNRK (C) whole cell lysates.

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！