Anti-MTOR antibody
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概述
- 产品描述The mechanistic target of rapamycin (mTOR), also known as the mammalian target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.
- 产品名称Anti-MTOR antibody
- 分子量289 kDa
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种属反应性Human,Mouse,Rat
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验证应用ICC,IHC-P
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抗体类型兔多抗
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免疫原Peptide
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偶联Non-conjugated
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性能
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形态Liquid
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浓度1 mg/mL.
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存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
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存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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亚型IgG
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纯化方式Peptide affinity purified
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亚细胞定位Endoplasmic reticulum, mitochondrion, nucleus.
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其它名称
more
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dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) antibody
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FK506 binding protein 12 rapamycin associated protein 1 antibody
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FK506 binding protein 12 rapamycin associated protein 2 antibody
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应用
ICC: 1:50-1:200
IHC-P: 1:50-1:200
WB: 1:200-1:500
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Fig1: ICC staining MTOR in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig2: ICC staining MTOR in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-MTOR antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-MTOR antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-MTOR antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-MTOR antibody. Counter stained with hematoxylin.
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