Anti-AP2 gamma antibody [A5-A11]

Anti-AP2 gamma antibody [A5-A11]

• 概述

• 产品描述AP-2 transcription factor family members include AP-2α, AP-2β and AP-2γ, which specifically bind to the DNA consensus sequence CCCCAGGC and initiate transcription of selected genes. AP-2, also known as ERF-1, plays a role in regulating estrogen receptor expression. AP-2β, a splice variant of AP-2α, inhibits AP-2 activity. Besides subscribing to the AP-2 complex, AP-2α, AP-2β and AP-2γ proteins compose the OB2-1 transcription factor complex. OB2-1 specifically upregulates expression of the proto-oncogene c-ErbB-2, which is overexpressed in 25-30% of breast cancers. AP-2α may play an important role in the development of ectodermal-derived tissues. Deleterious mutations involving the AP-2α gene are linked to microphthalmia, corneal clouding and other anterior eye chamber defects. The ubiquitously expressed AP-4 transcription factor specifically binds to the DNA consensus sequence 5′-CAGCTG-3′. AP-4 interacts with promoters for immunoglobulin-κ gene families and simian virus 40. AP-4 may enhance the transcription of the human Huntington's disease gene. AP-4 is a helix-loop-helix protein that contains two distinctive leucine repeat elements.
• 产品名称Anti-AP2 gamma antibody [A5-A11]
• 分子量49 kDa
• 种属反应性Human
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus.
• 其它名称
  • Activating enhancer binding protein 2 gamma antibody
  • Activating enhancer-binding protein 2 gamma antibody
  • AP2-gamma antibody
  more

• 应用

  WB: 1:500-1:2,000
  IHC-P: 1:50-1:200

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  Fig1: Western blot analysis of AP2 gamma on human AP2 gamma recombinant protein using anti- AP2 gamma antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of AP2 gamma on HEK293 (1) and AP2 gamma -hIgGFc transfected HEK293 (2) cell lysate using anti- AP2 gamma antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of AP2 gamma on SK-Br-3 cell lysate using anti- AP2 gamma antibody at 1/1,000 dilution.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissue using anti- AP2 gamma antibody. Counter stained with hematoxylin.

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