Anti-IgG1 antibody
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概述
- 产品描述disease:Chromosomal aberrations involving IGHG1 may be a cause of multiple myeloma. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16. 3;q32. 3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. miscellaneous:Disease protein OMM may represent an allelic form or another gamma chain subclass. miscellaneous:Disease protein WIS is lacking most of the V region and all of the CH1 region. miscellaneous:Disease protein ZUC lack most of the V region, all of the CH1 region, and part of the hinge compared with normal gamma-3 heavy chains. miscellaneous:EU also differs in the amidation states of residues 155, 166, 177, 195, 198, 269, and 272 and in the order of residues 268-272. miscellaneous:KOL also differs in the amidation states of residues 198, 267 and 272. miscellaneous:Nie also differs in the amidation states of 35, 116, 198, 269 and 272. miscellaneous:Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU sequences have the G1M(3) marker and the G1M (non-1) markers. miscellaneous:The hinge region in gamma-3 chains is about four times as long as in other gamma chains and contains three identical 15-residue segments preceded by a similar 17-residue segment (12-28). online information:IGHM mutation db,polymorphism:All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 216 have been observed in human mu chains. subcellular location:During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM. subunit:Dimer linked by 12 disulfide bonds; it has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region.
- 产品名称Anti-IgG1 antibody
- 分子量41 kDa
- 种属反应性Human
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human IgG1. AA range:196-245
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称IGHG1 antibody; Ig gamma-1 chain C region antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
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Fig1: Western Blot analysis of colo cells using IgG1 Polyclonal Antibody diluted at 1：500
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