Anti-CD151 antibody [3G1]

Anti-CD151 antibody [3G1]

• 概述

• 产品描述CD151 is involved in a wide variety of cell biological processes, includingcell adhesion and the transport of integrins via vesicles. The human CD151gene maps to chromosome 11p15.5 and encodes a 253 amino acid protein,which belongs to the tetraspan (4TM) superfamily. CD151 can associate with several Integrin chains including β1, β3, β4, α2, α3, α5 and α6 integrins. CD151 may provide a framework for the spatial organization of both type I and type II hemidesmosomes, which are specialized junctional complexes that function as cell-attachment sites for binding to basement membranes. CD151 RNA transcript (1.6 kb) can be detected in MO7e cells, bone marrow stromal cells, C11 endothelial cells, HUVEC and several myeloid leukemia cell lines, however, no transcript is detected in brain and the lymphoblastoid cell lines MOLT-4 and BALM-1. Leu149 -Glu213 of CD151 is the interface through which Integrins α3/β1 can bind. CD151 can enhance cell motility, invasion and metastasis of cancer cells in a focal adhesion kinase dependent manner.
• 产品名称Anti-CD151 antibody [3G1]
• 分子量28-32kDa
• 种属反应性Human
• 验证应用WB,IP,IF,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm, membrane
• 其它名称
  • CD151 antibody
  • CD151 antigen antibody
  • CD151 molecule (Raph blood group) antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-500
  IHC-P: 1:50-500

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  Fig1: Western blot analysis of CD151 expression in human platelet extract.

   

  

  Fig2: Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing membrane and cytoplasmic staining of glandular cells.

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