Anti-SNAIL antibody
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概述
- 产品描述The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3. The Snail-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription. Smuc preferentially associates with CAGGTG and CACCTG E-box motifs (CANNTG) on DNA and involves the five putative DNA-binding zinc finger domains at the C-terminal region of Smuc.
- 产品名称Anti-SNAIL antibody
- 分子量29 kDa, additional band 35 kDa
- 种属反应性Human,Mouse
- 验证应用WB,ICC,IHC-P
- 抗体类型兔多抗
- 免疫原Peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Nucleus. Cytoplasm.
- 其它名称dJ710H13.1 antibody
Protein sna antibody
Protein snail homolog 1 antibody
Protein snail homolog antibody
SLUGH2 antibody
SNA antibody
Sna protein antibody
SNAH antibody
SNAI antibody
snai1 antibody
SNAI1_HUMAN antibody
Snail 1 homolog antibody
Snail 1 zinc finger protein antibody
SNAIL antibody
Snail family transcriptional repressor 1 antibody
Snail homolog 1 (Drosophila) antibody
SNAIL, Drosophila, homolog of, 1 antibody
SNAIL1 antibody
Zinc finger protein SNAI1 antibody
more
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应用
WB: 1:500-1:1,000
ICC: 1:50-1:100
IHC-P: 1:50-1:200
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Fig1: Western blot analysis of SNAI1 on different lysates using anti-SNAI1 antibody at 1/500 dilution.
Positive control:
Lane 1: Human kidney tissue
Lane 2: SiHa
Lane 3: K562
Fig2: ICC staining SNAI1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining SNAI1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-SNAI1 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-SNAI1 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SNAI1 antibody. Counter stained with hematoxylin.
Fig7: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-SNAI1 antibody. Counter stained with hematoxylin.
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