Anti-KCNQ1 antibody [D3-E12]

Anti-KCNQ1 antibody [D3-E12]

• 概述

• 产品描述This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

• 产品名称Anti-KCNQ1 antibody [D3-E12]

• 分子量75kDa (Predicted band size)

• 种属反应性Human

• 验证应用WB,FC

• 抗体类型小鼠单抗

• 免疫原Recombinant protein

• 偶联Non-conjugated

• 性能

• 形态Liquid

• 浓度2 mg/mL.

• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.

• 亚型IgG2b

• 纯化方式Protein A purified.

• 亚细胞定位Membrane. Cytoplasm.

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• ​其它名称

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  • ATFB1 antibody

  • ATFB3 antibody

  • FLJ26167 antibody

• 应用

  WB: 1:500-1:2,000
  FC: 1:100-1:200

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  Fig1: Western blot analysis of KCNQ1 on human KCNQ1 recombinant protein using anti-KCNQ1 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of KCNQ1 on CF-7 (1) and A431 (2) cell lysate using anti-KCNQ1 antibody at 1/1,000 dilution.

   

  

  Fig3: Flow cytometric analysis of MCF-7 cells with KCNQ1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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