Anti-FUT4 antibody [B4-B11]

Anti-FUT4 antibody [B4-B11]

• 概述

• 产品描述Fucosyltransferases (FucTs) catalyze the covalent association of fucose to different positional linkages on sugar acceptor molecules. The carbohydrate moieties that are generated are covalently attached to cell surfaces and are necessary to ensure a surface contour that satisfies a variety of physiological roles. CD15, also known as Lewis X or LeX, is a carbohydrate antigen that is generated by FucT-IV (alpha 1,3-fucosyltransferase IV). Commonly found on the surface of leukocytes and some tumor cells, CD15 is a trisaccharide that is synthesized when FucT-IV transfers an α-fucose residue onto the β-GlcNAc moiety of cellular N-acetyllactosamines. CD15 functions as an adhesion molecule capable of calcium-mediated homotypic binding. Cells with high surface expression of CD15, therefore, exhibit strong self-aggregation (based on CD15-CD15 interaction) in the presence of calcium. Additionally, CD15 is thought to be a ligand for Selectins (proteins involved in mediating leukocyte-specific cellular interactions), further supporting its role as a cell-adhesion protein.

• 产品名称Anti-FUT4 antibody [B4-B11]

• 分子量59 kDa

• 种属反应性Human

• 验证应用WB

• 抗体类型小鼠单抗

• 免疫原Recombinant protein

• 偶联Non-conjugated

• 性能

• 形态Liquid

• 浓度2 mg/mL.

• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

• 亚型IgG2b

• 纯化方式Protein A purified.

• 亚细胞定位Golgi Apparatus, membrane-bound form in trans cisternae of Golgi.

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• ​其它名称

  more

  • 3)-fucosyltransferase antibody

  • Alpha-(1 antibody

  • Alpha-(1,3)-fucosyltransferase antibody

• 应用

  WB: 1:500-1:2,000

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  Fig1: Western blot analysis of FUT4 on human FUT4 recombinant protein using anti-FUT4 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of FUT4 on HEK293 (1) and FUT4-hIgGFc transfected HEK293 (2) cell lysate using anti-FUT4 antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of FUT4 on Jurkat cell lysate using anti-FUT4 antibody at 1/1,000 dilution.

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