Anti-IL1R1 antibody [D12-D2]

Anti-IL1R1 antibody [D12-D2]

• 概述

• 产品描述Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Among the activities regulated by IL-1 are fever, acute phase responses, degradation of connective tissue and immunostimulatory activities. The IL-1Rα molecule also binds specifically to IL-1Rs, but fails to initiate intracellular responses. Two distinct IL-1Rs have been identified, each of which belongs to the Ig superfamily and is widely expressed in a broad range of cells and tissues. Although many cell types co-express type I and type II receptors, there is no evidence that these constitute subunits of a single complex. The type II receptor has a short 29 amino acid cytoplasmic domain that does not seem sufficient for signaling while in fact there is considerable evidence arguing that IL-1 signals exclusively through the type I IL-1R.
• 产品名称Anti-IL1R1 antibody [D12-D2]
• 分子量65 kDa
• 种属反应性Human
• 验证应用WB,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane, Secreted.
• 其它名称
  • Antigen CD121a antibody
  • CD121 antigen-like family member A antibody
  • CD121a antibody
  more

• 应用

  WB: 1:500-1:2,000
  FC: 1:100-1:200

•  

  

  Fig1: Western blot analysis of IL1R1 on human IL1R1 recombinant protein using anti-IL1R1 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of IL1R1 on HEK293 (1) and IL1R1-hIgGFc transfected HEK293 (2) cell lysate using anti-IL1R1 antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of IL1R1 on Hela cells lysate using anti-IL1R1 antibody at 1/1,000 dilution.

   

  

  Fig4: Flow cytometric analysis of Hela cells with IL1R1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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