Anti-VIMP antibody [G1-F8]

Anti-VIMP antibody [G1-F8]

• 概述

• 产品描述Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of Selenoproteins. Nutritional deficiency of selenium decreases Selenoprotein concentrations and leads to pathologic conditions. Most of the known Selenoproteins are members of the glutathione peroxidase or iodothyronine deiodinase families. Selenoprotein S, also known as VIMP or SELS, is a 189 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum (ER) and contains a selenocysteine (Sec) residue at its active site. Interacting with Derlin-1 and VCP, Selenoprotein S is involved in the degradation of misfolded ER proteins, specifically participating in the transfer of misfolded proteins from the ER to the cytosol for subsequent proteasomal degradation. Aberrant expression of Selenoprotein S is associated with diabetes, cardiovascular disease and rheumatoid arthritis.
• 产品名称Anti-VIMP antibody [G1-F8]
• 分子量21 kDa
• 种属反应性Human
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2b
• 纯化方式Protein A purified.
• 亚细胞定位Endoplasmic reticulum membrane. Cytoplasm.
• 其它名称
  • AD-015 antibody
  • ADO15 antibody
  • MGC104346 antibody
  more

• 应用

  WB: 1:500-1:2,000
  IHC-P: 1:100-1:200

•  

  

  Fig1: Western blot analysis of VIMP on human VIMP recombinant protein using anti-VIMP antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of VIMP on HEK293 (1) and VIMP-hIgGFc transfected HEK293 (2) cell lysate using anti-VIMP antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of VIMP on different cell lysate using anti-VIMP antibody at 1/1,000 dilution.
  Positive control:
  Lane 1: MCF-7
  Lane 2: PANC-1
  Lane 3: Jurkat
  Lane 4: HepG2
  Lane 5: MOLT4
  Lane 6: U251
  Lane 7: A431

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-VIMP antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue using anti-VIMP antibody. Counter stained with hematoxylin.

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