Anti-VAV1 antibody [C10-E11]

Anti-VAV1 antibody [C10-E11]

• 概述

• 产品描述The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. This protein, known as Vav, Vav1 or p95Vav, contains an N-terminal helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins that, if deleted, causes oncogenic activation. In addition, Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages. These results suggest that Vav may represent a new type of signal transduction molecule involved in the transduction of tyrosine phosphorylation signaling into transcriptional events.
• 产品名称Anti-VAV1 antibody [C10-E11]
• 分子量98 kDa
• 种属反应性Human
• 验证应用WB,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytosol.
• 其它名称
  • Oncogene vav antibody
  • p95Vav antibody
  • Proto-oncogene vav antibody
  more

• 应用

  WB: 1:500-1:1,000
  FC: 1:100-1:200

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  Fig1: Western blot analysis of VAV1 on Jurkat cell lysate using anti-VAV1 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of VAV1 on human VAV1 recombinant protein using anti-VAV1 antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of VAV1 on HEK293 (1) and VAV1-hIgGFc transfected HEK293 (2) cell lysate using anti-VAV1 antibody at 1/1,000 dilution.

   

  

  Fig4: Flow cytometric analysis of Hela cells with VAV1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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