Anti-Epac1 antibody [4G3]

Anti-Epac1 antibody [4G3]

• 概述

• 产品描述3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac (Epac1, cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the Ras family GTPases Rap 1 and Rap 2 by promoting GTP binding in a cAMP-dependent manner. Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission. The human Epac gene maps to chromosome 12q13.11 with transcript being abundant in the kidney and heart. In situ hybridization indicates expression of Epac in adult rat brain and selective expression in neonatal brain, including septum and thalamus.
• 产品名称Anti-Epac1 antibody [4G3]
• 分子量99 kDa
• 种属反应性Human,Rat,Hamster
• 验证应用WB,IP,IF,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Endomembrane system
• 其它名称
  • bcm910 antibody
  • CAMP GEFI antibody
  • cAMP regulated guanine nucleotide exchange factor I antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500
  IHC-P: 1:50-1:500

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  Fig1: A.Western blot analysis of Epac expression in Caki (A) and CHO (B) whole celllysates.

   

  

  Fig2: B.Western blot analysis of Epac expression in HeLa whole cell lysate.

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！