Anti-SATB2 antibody [4G03]

Anti-SATB2 antibody [4G03]

• 概述

• 产品描述SATB2 (special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF-4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.
• 产品名称Anti-SATB2 antibody [4G03]
• 分子量105kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IF
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus matrix
• 其它名称
  • DNA binding protein SATB2 antibody
  • DNA-binding protein SATB2 antibody
  • FLJ21474 antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500
  IHC-P: 1:50-1:500
  FC: 1 μg per 1 x 106 cells

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  Fig1: Western blot analysis of SATB2 expression in KNRK (A), HT-1080 (B) and SH-SY5Y (C) nuclear extracts.

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！