Anti-ATRX antibody [2-E7]

Anti-ATRX antibody [2-E7]

• 概述

• 产品描述Transcriptional regulator ATRX contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations of the ATRX gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes.
• 产品名称Anti-ATRX antibody [2-E7]
• 分子量280 kDa
• 种属反应性Mouse
• 验证应用ICC,IHC-P
• 抗体类型小鼠单抗
• 免疫原This antibody is produced by immunizing mice with recombinant protein of mouse ATRX.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein G purified.
• 亚细胞定位Nucleus
• 其它名称
  • Alpha thalassemia/mental retardation syndrome X linked homolog antibody
  • ATP dependent helicase ATRX antibody
  • ATP-dependent helicase ATRX antibody
  more

• 应用

  ICC: 1:200
  IHC-P: 1:200

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  Fig1: ICC staining ATRX in mouse embryonic cells D3 (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig2: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti- ATRX mouse monoclonal antibody.

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