Anti-DKK3 antibody [C6-A5]

Anti-DKK3 antibody [C6-A5]

• 概述

• 产品描述Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
• 产品名称Anti-DKK3 antibody [C6-A5]
• 分子量38 kDa
• 种属反应性Human
• 验证应用WB,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Secreted.
• 其它名称
  • Dickkopf 3 antibody
  • Dickkopf 3 homolog (Xenopus laevis) antibody
  • Dickkopf 3 homolog antibody
  more

• 应用

  WB: 1:500-1:1,000
  IHC-P: 1:50-1:200

•  

  

  Fig1: Western blot analysis of DKK3 on human DKK3 recombinant protein using anti-DKK3 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of DKK3 on HEK293 (1) and DKK3-hIgGFc transfected HEK293 (2) cell lysate using anti-DKK3 antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-DKK3 antibody. Counter stained with hematoxylin

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