Anti-PTH1R antibody [A5-D2]

Anti-PTH1R antibody [A5-D2]

• 概述

• 产品描述Parathyroid hormone (PTH), which is also designated parathyrin, is an 84 amino acid single chain peptide that functions to regulate calcium metabolism by raising blood levels of calcium through various mechanisms. Parathyroid hormone-related protein (PTH-rP) is an autocrine factor that is structurally related to PTH yet, unlike PTH, which is synthesized only by the parathyroid cells, PTH-rP is synthesized by several cell types. PTH-rP regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Isolated from the culture medium of a human lung cancer cell line, PTH-rP produces PTH-like effects that are characterized as humoral hypercalcemia of malignancy. PTH and PTH-rP are both regulated by vitamin D and steroid hormones and preferentially bind to specific PTH/PTH-rP receptors, then activate adenylate cyclase or PLC β via PKC activation.
• 产品名称Anti-PTH1R antibody [A5-D2]
• 分子量66 kDa
• 种属反应性Human
• 验证应用WB,ICC,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cell membrane.
• 其它名称
  • MGC138426 antibody
  • MGC138452 antibody
  • Parathyroid hormone 1 receptor antibody
  more

• 应用

  WB: 1:500-1:1,000
  ICC: 1:50-1:200
  IHC-P: 1:100-1:500

•  

  

  Fig1: Western blot analysis of PTH1R on PTH1R-hIgGFc transfected HEK293 cell lysate using anti-PTH1R antibody at 1/1,000 dilution.

   

  

  Fig2: ICC staining PTH1R (green) in SK-BR-3 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PTH1R antibody. Counter stained with hematoxylin.

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