Anti-KDR / VEGFR-2 antibody [1G1]
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概述
- 产品描述Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulinlike sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.
- 产品名称Anti-KDR / VEGFR-2 antibody [1G1]
- 分子量200kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IP,IF,IHC-P
- 抗体类型小鼠单抗
- 免疫原Amino acids 1158-1345 mapping at the C-terminus of the Flk-1 of mouse origin.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG1
- 纯化方式Protein A purified.
- 亚细胞定位Cytoplasm, Nucleus, Secreted, Cell junction Endoplasmic reticulum, Cell membrane, Cytoplasmic vesicle, Early endosome
- 其它名称
- CD309 antibody
- CD309 antigen antibody
- EC 2.7.10.1 antibody
more
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应用
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
IF: 1:50-1:500
IHC-P: 1:50-1:500
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Fig1: Western blot analysis of Flk-1 expression in non-transfected (A) and mouse Flk-1 transfected (B) 293T whole cell lysates.
Fig2: Western blot analysis of Flk-1 expression in VEGF-treated HUV-EC-C whole cell lysate.
特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!