Anti-Caspase-1 antibody [B0-6]

Anti-Caspase-1 antibody [B0-6]

• 概述

• 产品描述Caspase 1 is produced as a?zymogen?that is cleaved into 20 kDa (p20) and 10 kDa (p10) subunits that become part of the active enzyme. Active caspase 1 contains two?heterodimers?of p20 and p10. It interacts with another?CARD domain?containing protein called?PYCARD?(or ASC) and is involved in?inflammasome?formation and activation of?inflammatory?processes. Caspase 1 has been shown to induce cell?necrosis?or?pyroptosis?and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of?Huntington's disease.?Alternative splicing?of the gene results in five transcript variants encoding distinct isoforms.?Recent studies implicated caspase 1 in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS.
• 产品名称Anti-Caspase-1 antibody [B0-6]
• 分子量45kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB, ICC, IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm
• 其它名称
  • CASP-1 antibody
  • CASP1 antibody
  • CASP1_HUMAN antibody
  more

• 应用

  WB: 1:2,000-1:5,000
  IHC-P: 1:200-1:500
  ICC: 1:200

•  

  

  Fig1: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti- Caspase-1 Mouse mAb.

   

  

  Fig2: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- Caspase-1 Mouse mAb.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti- Caspase-1 Mouse mAb.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti- Caspase-1 Mouse mAb.

   

  

  Fig5: ICC staining Caspase-1 in NIH/3T3 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

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