Anti-Active+Pro Caspase-9 antibody
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概述
- 产品描述Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. It is known to be involved in the activation cascade of caspases responsible for apoptosis execution. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis.
- 产品名称Anti-Active+Pro Caspase-9 antibody
- 分子量46 kDa (Predicted band size)
- 种属反应性Human
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原Synthetic peptide within human Caspase-9 aa 299-313/416.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cytoplasm
- 其它名称
- APAF-3 antibody
- APAF3 antibody
- Apoptosis related cysteine peptidase antibody
more
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应用
WB: 1:1,000- 1:2,000
IHC-P: 1:200
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Fig1: Western blot analysis on Hela cell lysates using anti-Caspase-9 rabbit polyclonal antibodies with Dilution at 1:500 (1) and 1:1000 (2).
Fig2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti-Caspase-9 rabbit polyclonal antibody.
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