Anti-ILK antibody
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概述
- 产品描述Integrins are heterodimers composed of non-covalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind to ligands that are components of the extracellular matrix. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells,such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. In addition to mediating cell adhesion and cytoskeletal organization,integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation,migration and apoptosis. ILK (integrin-linked kinase) was identified as a serine/threonine kinase that phosphorylates β1 and β3 integrins. ILK expression has been shown to be reduced in response to fibronectin, a known integrin ligand.Overexpression of ILK was shown to upregulate the fibronectin matrix assembly in epithelial cells, indicating a potential role for ILK in cell growth, cell survival and tumorigenesis.
- 产品名称Anti-ILK antibody
- 分子量59kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IP,IF
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cytoplasm, Cell junction, Cell membrane Cell projection
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- 其它名称
- 59 kDa serine/threonine protein kinase antibody
- 59 kDa serine/threonine-protein kinase antibody
- DKFZp686F1765 antibody
more
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应用
WB: 1:1,000
IP: 1-2 μg per 100-500 μg of total protein
IF: 1:50-500
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Fig1: Western blot analysis of ILK expression in HeLa whole cell lysate.
Fig2: Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
