Anti-IGF2R/M6PR antibody
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概述
- 产品描述The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.
- 产品名称Anti-IGF2R/M6PR antibody
- 分子量274 kDa
- 种属反应性Human
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种属反应性Human
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验证应用ICC,IHC-P,FC
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抗体类型兔多抗
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免疫原recombinant protein
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偶联Non-conjugated
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性能
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形态Liquid
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浓度1 mg/mL.
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存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
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存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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亚型IgG
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纯化方式Peptide affinity purified
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亚细胞定位Lysosome membrane, Secreted, Nucleus
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其它名称
more
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300 kDa mannose 6 phosphate receptor antibody
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300 kDa mannose 6-phosphate receptor antibody
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Cation independent mannose 6 phosphate receptor antibody
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应用
ICC: 1:50-1:200
IHC-P: 1:50-1:200
FC: 1:50-1:100
WB: 1:500-1:1,000
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Fig1: Immunocytochemical staining of Hela cells using anti-M6PR rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of SW480 cells using anti-M6PR rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of MCF-7 cells using anti-M6PR rabbit polyclonal antibody.
Fig4: Immunohistochemical analysis of paraffin- embedded human tonsil tissue using anti-M6PR rabbit polyclonal antibody.
Fig5: Immunohistochemical analysis of paraffin- embedded human lung carcinoma tissue using anti-M6PR rabbit polyclonal antibody.
Fig6: Flow cytometric analysis of Hela cells with M6PR antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti mouse IgG was used as the secondary antibody.
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
