Anti-ERK1 antibody [7-D6-E5]

Anti-ERK1 antibody [7-D6-E5] 

• 概述

• 产品描述Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs, such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines , and research investigators consider it an important target in the diagnosis and treatment of cancer . Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family, as well as Mos and Tpl2/COT. MEK1 and MEK2 are the primary MAPKKs in this pathway.
• 产品名称Anti-ERK1 antibody [7-D6-E5]
• 分子量43 kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,ICC
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm, nucleus, Endoplasmic reticulum membrane
• 其它名称
  • ERK 1 antibody
  • ERK antibody
  • ERK-1 antibody
  more

• 应用

  WB: 1:5,000-1:10,000
  ICC: 1:200

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  Fig1: Western blot analysis on Hela cell lysates using anti-ERK1 mouse mAb.

   

  

  Fig2: ICC staining ERK1 in HepG2 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

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