Anti-RUNX2 antibody
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概述
- 产品描述The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.
- 产品名称Anti-RUNX2 antibody
- 分子量56.6 kDa
- 种属反应性Human
- 验证应用WB,IHC-P,ICC
- 抗体类型兔多抗
- 免疫原Synthetic peptide of C-terminal human RUNX2.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified.
- 亚细胞定位Nucleus.
- 其它名称Acute myeloid leukemia 3 protein antibody
Alpha subunit 1 antibody
AML3 antibody
CBF alpha 1 antibody
CBF-alpha-1 antibody
CBFA1 antibody
CCD antibody
CCD1 antibody
Cleidocranial dysplasia 1 antibody
Core binding factor antibody
Core binding factor runt domain alpha subunit 1 antibody
Core binding factor subunit alpha 1 antibody
Core-binding factor subunit alpha-1 antibody
MGC120022 antibody
MGC120023 antibody
Oncogene AML 3 antibody
Oncogene AML-3 antibody
OSF 2 antibody
OSF-2 antibody
OSF2 antibody
Osteoblast specific transcription factor 2 antibody
Osteoblast-specific transcription factor 2 antibody
OTTHUMP00000016533 antibody
PEA2 alpha A antibody
PEA2-alpha A antibody
PEA2aA antibody
PEBP2 alpha A antibody
PEBP2-alpha A antibody
PEBP2A1 antibody
PEBP2A2 antibody
PEBP2aA antibody
PEBP2aA1 antibody
Polyomavirus enhancer binding protein 2 alpha A subunit antibody
Polyomavirus enhancer-binding protein 2 alpha A subunit antibody
Runt domain antibody
Runt related transcription factor 2 antibody
Runt-related transcription factor 2 antibody
RUNX2 antibody
RUNX2_HUMAN antibody
SL3 3 enhancer factor 1 alpha A subunit antibody
SL3-3 enhancer factor 1 alpha A subunit antibody
SL3/AKV core binding factor alpha A subunit antibody
SL3/AKV core-binding factor alpha A subunit antibody
more
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应用
WB: 1:500
ICC: 1:50-1:200
IHC-P: 1:50-1:200
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Fig1: Western blot analysis of RUNX2 on HL-60 cell lysate using anti-RUNX2 antibody at 1/500 dilution.
Fig2: ICC staining RUNX2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-RUNX2 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-RUNX2 antibody. Counter stained with hematoxylin.
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