Anti-5HT1A Receptor antibody
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概述
- 产品描述G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
- 产品名称Anti-5HT1A Receptor antibody
- 分子量46 KDa
- 种属反应性Human, Mouse, Rat, Dog, Horse, Rabbit
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human 5-HTR1A 301-400/422
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Affinity purified by Protein A
- 亚细胞定位Cell membrane; Multi-pass membrane protein.
- 其它名称5HT1A Receptor
HTR1A
5-HTR1A
5 HT 1A
5 HT receptor 1A
5 HT1A
5 HT1A receptor
5 hydroxytryptamine (serotonin) receptor 1A
5 hydroxytryptamine (serotonin) receptor 1A G protein coupled
5 hydroxytryptamine receptor 1A
5-HT-1A
5-HT1A
5-hydroxytryptamine receptor 1A
5HT 1A
5HT 1A receptor
5HT receptor 1A
5HT1a
5HT1A_HUMAN
ADRB2RL1
ADRBRL1
G 21
G protein coupled receptor
G-21
Gpcr 18
Gpcr18
Guanine nucleotide binding regulatory protein-coupled receptor
PFMCD
Serotonin 1A receptor
Serotonin 5HT1A receptor
Serotonin receptor 1A
more
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应用
WB:1:500-2000
IHC-P:1:400-800
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Fig1: Protein: HepG2 lyates(hu);
Primary: Rabbit Anti- 5HT1A Receptor at 1:300;
Secondary: 800CW Conjugated Goat (polyclonal) Anti-Rabbit IgG(H+L) at 1: 10000;
Predicted band size:46 kD Observed band size:56 kD
Fig2: Protein: Brain(Mouse) Lysate at 40 ug
Primary: Rabbit Anti- 5HT1A Receptor at 1:300;
Secondary: 800CW Conjugated Goat (polyclonal) Anti-Rabbit IgG(H+L) at 1: 10000;
Predicted band size:46 kD Observed band size:56 kD
Fig3: Sample:
Jurkat(Human) Cell Lysate at 40 ug
Primary: Anti-5HT1A Receptorat 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 46 kD
Observed band size: 46 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
