Anti-CBARA1 antibody
-
概述
- 产品描述Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Alternatively spliced transcript variants encoding different isoforms have been described.
- 产品名称Anti-CBARA1 antibody
- 分子量45 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Recombinant protein within Human CBARA1 aa 14-154.
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein affinity purified.
- 亚细胞定位Mitochondrion.
- 其它名称Allergen Hom s 4 antibody
ara CALC antibody
atopy related autoantigen antibody
atopy related autoantigen CALC antibody
Atopy-related autoantigen CALC antibody
CALC antibody
calcium binding atopy related autoantigen 1 antibody
Calcium uptake protein 1 antibody
calcium uptake protein 1, mitochondrial antibody
Calcium-binding atopy-related autoantigen 1 antibody
CBARA1 antibody
EFHA3 antibody
FLJ12684 antibody
MICU1 antibody
MICU1_HUMAN antibody
mitochondrial antibody
mitochondrial calcium uptake 1 antibody
MPXPS antibody
more
-
-
Fig1: Western blot analysis of CBARA1 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody was used at a 1:500 dilution in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.
Positive control:
Lane 1: Mouse kidney tissue lysate
Lane 2: Rat brain tissue lysate
Lane 3: Hela cell lysate
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
