Anti-TAB1 antibody [1G2]

Anti-TAB1 antibody [1G2]

• 概述

• 产品描述The TAK1 binding proteins, TAB1, TAB2 and TAB3, interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGFβ mediated signaling. TAB1 also plays a central role in a p38α activation pathway that is independent of MAPKK. In response to pro-inflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. When overexpressed, TAB3 activates both NFκB and AP-1 transcription factors. In response to TNFα or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes.
• 产品名称Anti-TAB1 antibody [1G2]
• 分子量56kDa
• 种属反应性Human
• 验证应用WB,IP,IF
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位--
• 其它名称
  • 2310012M03Rik antibody
  • 3'-Tab1 antibody
  • MAP3K7IP 1 antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500

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  Fig1: Western blot analysis of TAB1 expression in non-transfected (A) and human TAB1 transfected (B) 293T whole cell lysates.

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