Anti-Fish antibody
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概述
- 产品描述domain:The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19. domain:The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2). Required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide. PTM:Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Belongs to the SH3PXD2 family. Contains 1 PX (phox homology) domain. Contains 5 SH3 domains. subcellular location:Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. subunit:Interacts with ADAM12, ADAM15 and ADAM19. tissue specificity:Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
- 产品名称Anti-Fish antibody
- 种属反应性Human,Mouse
- 验证应用IHC-P,WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from the N-terminal region of human Fish.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称SH3PXD2A antibody; FISH antibody; KIAA0418 antibody; SH3MD1 antibody; TKS5 antibody; SH3 and PX domain-containing protein 2A antibody; Adapter protein TKS5 antibody; Five SH3 domain-containing protein antibody; SH3 multiple domains protein 1 antibody; Tyrosine kinase substrate with five SH3 domains antibody;
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应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
