Anti-IGFBP7 antibody [E7-D9]

Anti-IGFBP7 antibody [E7-D9]

• 概述

• 产品描述The Insulin-like growth factor-binding proteins (IGFBPs) are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP-7 is a secreted protein that binds both IGF-I and IGF-II with a relatively low affinity. It stimulates pros-tacyclin production and may also function as a growth-suppressing factor.

• 产品名称Anti-IGFBP7 antibody [E7-D9]

• 分子量29 kDa

• 种属反应性Human

• 验证应用WB,IHC-P

• 抗体类型小鼠单抗

• 免疫原Recombinant protein

• 偶联Non-conjugated

• 性能

• 形态Liquid

• 浓度2 mg/mL.

• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

• 亚型IgG1

• 纯化方式Protein A purified.

• 亚细胞定位Secreted.

   

• 其它名称

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• 应用

  WB: 1:500-1:2,000
  IHC-P: 1:100-1:200

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  Fig1: Western blot analysis of IGFBP7 on human IGFBP7 recombinant protein using anti-IGFBP7 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of IGFBP7 on HEK293 (1) and IGFBP7-hIgGFc transfected HEK293 (2) cell lysate using anti-IGFBP7 antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-IGFBP7 antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-IGFBP7 antibody. Counter stained with hematoxylin.

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