Anti-TAL1 / SCL LS-C182473 antibody [4G1]

Anti-TAL1 / SCL LS-C182473 antibody [4G1] 

• 概述

• 产品描述Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of casein kinase IIα, a serine/ threonine protein kinase known to modulate the activity of other βHLH transcription factors.
• 产品名称Anti-TAL1 / SCL LS-C182473 antibody [4G1]
• 分子量42kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IF
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus
• 其它名称
  • bHLHa17 antibody
  • Class A basic helix-loop-helix protein 17 antibody
  • OTTHUMP00000009563 antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500

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  Fig1: Western blot analysis of TAL1 expression in non-transfected (A) and human TAL1 transfected (B) 293T whole cell lysates and CCRF-CEM (C), Jurkat (D) and K-562 (E) nuclear extracts.

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