Anti-GPNMB antibody [E5-C10]

Anti-GPNMB antibody [E5-C10]

• 概述

• 产品描述Transmembrane glycoprotein NMB (GPNMB), also designated hematopoietic growth factor inducible neurokinin-1 (HGFIN), is a single-pass type I membrane protein. Belonging to the Pmel-17/NMB family of proteins, GPNMB acts as a melanogenic enzyme. GPNMB expression is not restricted to cells of melanocytic lineage and is highest in poorly metastatic melanoma cell lines. There is no expression of GPNMB in highly metastatic melanoma cell lines. GPNMB may play a important role in lymphohematopoietic stem cell maturation.

• 产品名称Anti-GPNMB antibody [E5-C10]

• 分子量64 kDa

• 种属反应性Human

• 验证应用WB,IHC-P

• 抗体类型小鼠单抗

• 免疫原Recombinant protein

• 偶联Non-conjugated

• 性能

• 形态Liquid

• 浓度2 mg/mL.

• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

• 亚型IgG1

• 纯化方式Protein A purified.

• 亚细胞定位Membrane. Melanosome.

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• ​其它名称

  more

  • Glycoprotein (transmembrane) nmb antibody

  • Glycoprotein nmb antibody

  • Glycoprotein nmb like protein antibody

• 应用

  WB: 1:500
  IHC-P: 1:100-1:200

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  Fig1: Western blot analysis of GPNMB on human GPNMB recombinant protein using anti-GPNMB antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of GPNMB on HEK293 (1) and GPNMB-hIgGFc transfected HEK293 (2) cell lysate using anti-GPNMB antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of GPNMB on PANC-1 and PC-3 cell lysate using anti-GPNMB antibody at 1/1,000 dilution.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-GPNMB antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue using anti-GPNMB antibody. Counter stained with hematoxylin.

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