Anti-C1QA antibody [G3-C7]

Anti-C1QA antibody [G3-C7]

• 概述

• 产品描述C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorder characterized by lupus-like symptoms.
• 产品名称Anti-C1QA antibody [G3-C7]
• 分子量26 kDa
• 种属反应性Human
• 验证应用WB,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2b
• 纯化方式Protein A purified.
• 亚细胞定位Secreted.
• 其它名称
  • C1qa antibody
  • C1QA_HUMAN antibody
  • Complement C1q subcomponent subunit A antibody
  more

• 应用

  WB: 1:500-1:2,000
  IHC-P: 1:100-1:500
  FC: 1:100-1:200

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  Fig1: Western blot analysis of C1QA on human C1QA recombinant protein using anti-C1QA antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of C1QA on HEK293 (1) and C1QA-hIgGFc transfected HEK293 (2) cell lysate using anti-C1QA antibody at 1/1,000 dilution.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using anti-C1QA antibody. Counter stained with hematoxylin.

   

  

  Fig4: Flow cytometric analysis of Hela cells with C1QA antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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