Anti-PRDX2 antibody [7F2]

Anti-PRDX2 antibody [7F2]

• 概述

• 产品描述The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis.
• 产品名称Anti-PRDX2 antibody [7F2]
• 分子量22 kDa
• 种属反应性Human
• 验证应用IHC-P,WB,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein G purified.
• 亚细胞定位Cytoplasm.
• 其它名称
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• 应用

  WB: 1:2000-1:5000
  IHC-P: 1:50-1:200
  FC: 1:50-1:200

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  Fig1: Western blot analysis of Peroxiredoxin 2 on PC-3M (1) and MCF-7 (2) using anti-Peroxiredoxin 2 antibody at 1/2,000 dilution.

   

  

  Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti- Peroxiredoxin 2 antibody. Counter stained with hematoxylin.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using anti- Peroxiredoxin 2 antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue using anti- Peroxiredoxin 2 antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti- Peroxiredoxin 2 antibody. Counter stained with hematoxylin.

   

  

  Fig6: Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti- Peroxiredoxin 2 antibody. Counter stained with hematoxylin.

   

  

  Fig7: Flow cytometric analysis of Jurkat cells with Peroxiredoxin 2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-mouse IgG was used as th

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