Anti-Insulin antibody [5E1]

Anti-Insulin antibody [5E1]

• 概述

• 产品描述Insulin is a secreted peptide hormone that elicits metabolic effects such as increases in glucose uptake and glycogen synthesis leading to a decrease in blood glucose concentration. Insulin is first formed as a precursor molecule, preproinsulin, which is later cleaved to proinsulin and finally to the mature insulin hormone. Mature insulin consists of 51 amino acids, contained within an A chain and a B chain that are connected by two disulfide bridges. It increases cell permeability to monosaccharides, amino acids and fatty acids. Insulin is secreted by the pancreas at basal levels in the absence of exogenous stimuli, with secretion increasing in response to glucose. Insulin action is effected by the binding of insulin to cell-surface receptors on the target cell membrane. Defects of insulin are the cause of hyperproinsulinemia and of type-II diabetes mellitus.
• 产品名称Anti-Insulin antibody [5E1]
• 分子量12 kDa
• 种属反应性Human
• 验证应用WB,ELISA,IHC-P
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度1 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Secreted.
• 其它名称
  • IDDM antibody
  • IDDM1 antibody
  • IDDM2 antibody
  more

• 应用

  IHC-P: 1:2,000-1:10,000
  WB: 1:1,000-1:5,000

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  Fig1: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Insulin antibody. Counter stained with hematoxylin.

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