Anti-SIRT1 antibody [7-C5-B2]

Anti-SIRT1 antibody [7-C5-B2]

• 概述

• 产品描述SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARγ, and the PPARγ coactivator-1α (PGC-1α) protein. Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol.
• 产品名称Anti-SIRT1 antibody [7-C5-B2]
• 分子量110kDa
• 种属反应性Human,Mouse
• 验证应用WB,ICC,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2b
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus, Cytoplasm,
• 其它名称
  • 75SirT1 antibody
  • hSIR2 antibody
  • hSIRT1 antibody
  more

• 应用

  IHC-P: 1:200
  ICC: 1:200-1:500
  WB: 1:500

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  Fig1: ICC staining SIRT1 in Hela cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti- SIRT1 mouse mAb.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti- SIRT1 mouse mAb.

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