Anti-Phospholamban antibody [1G3]

Anti-Phospholamban antibody [1G3]

• 概述

• 产品描述The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated phospho-protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser 10, Ser 16, Thr 17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.
• 产品名称Anti-Phospholamban antibody [1G3]
• 分子量Oligomer: 25 kDa, Monomer: 6 kDa
• 种属反应性Human, Mouse, Rat
• 验证应用WB, IP, IF
• 抗体类型小鼠单抗
• 免疫原Specific for an epitope mapping between amino acids 7-32 at the N-terminus of phospholamban of human origin.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度0.5 mg/mL.
• 存放说明Store at +4℃.
• 存储缓冲液1*TBS (pH7.4), 1%BSA. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Sarcoplasmic reticulum membrane Mitochondrion membrane, Endoplasmic reticulum membrane
• 其它名称
  • Cardiac phospholamban antibody
  • CMD1P antibody
  • CMH18 antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500

•  

  

  Fig1: Western blot analysis of phospholamban expression in mouse heart (A) and human heart (B) tissue extracts.

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！