Anti-Iba1 antibody
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概述
- 产品描述Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor-1 (AIF-1), is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC).
- 产品名称Anti-Iba1 antibody
- 分子量17 kDa
- 种属反应性Human, Mouse, Rat
- 验证应用WB, ICC, IHC-P, FC, IP
- 抗体类型小鼠单抗
- 免疫原Recombinant protein.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃.
- 存储缓冲液Each vial contains 200 µg IgG2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
- 亚型IgG
- 纯化方式ProA affinity purified.
- 亚细胞定位Cytoplasm, cytoskeleton.
- 其它名称
- AIF 1 antibody
- AIF-1 antibody
- Aif1 antibody
more
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应用
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
ICC: 1:50-1:500
IHC-P: 1:50-1:500
FC: 1 μg per 1 x 106 cells
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Fig1: Western blot analysis of Iba1 on human PBL whole cell lysate using anti-Iba1 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded rat C6 glioblastoma tissue using anti-Iba1 antibody. Counter stained with hematoxylin.
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