Anti-CD141 antibody [2G1]

Anti-CD141 antibody [2G1]

• 概述

• 产品描述Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.
• 产品名称Anti-CD141 antibody [2G1]
• 分子量105kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane
• 其它名称
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• 应用

  WB: 1:500-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IHC-P: 1:50-500 FCM: 1 μg per 1 x 106 cells

•  

  

  Fig1: Western blot analysis of TM expression in non-transfected (A) and human TM transfected (B) 293T whole cell lysates.

   

  

  Fig2: Immunofluorescence staining of methanol-fixed THP-1 cells showing membrane localization (A). Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic and membrane staining of trophoblastic cells (B).

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