Anti-CD11c / ITGAX antibody [3G1]

Anti-CD11c / ITGAX antibody [3G1] 

• 概述

• 产品描述Integrin ?X (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with ∫2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin ?X/∫2 shares similar properties of the ?M/∫2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin ?X is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin ?X include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin ?X is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.
• 产品名称Anti-CD11c / ITGAX antibody [3G1]
• 分子量145kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,IP,IF,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane
• 其它名称
  • 95 alpha chain antibody
  • 95 antibody
  • CD 11c antibody
  more

• 应用

  WB: 1:100-1:1,0000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-500
  IHC-P: 1:50-500

•  

  

  Fig1: Western blot analysis of Integrin αX expression in non-transfected 293T (A), human Integrin αX transfected 293T (B) and HL-60 (C) whole cell

   

  

  Fig2: Western blot analysis of Integrin αX expression in AML-193 whole cell lysate.

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