Anti-Beta-catenin antibody [10-C0-B7]

Anti-Beta-catenin antibody [10-C0-B7]

• 概述

• 产品描述Catenin (cadherin-associated protein), beta 1, 88kDa, also called beta-catenin (or β-catenin), is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. The cellular level of beta-catenin is mostly controlled by its ubiquitinylation and proteosomal degradation. Cell–cell adhesion complexes are essential for the formation of complex animal tissues. β-catenin is part of a protein complex that form the so-called adherens junctions. Beta-catenin has a central role in directing several developmental processes, as it can directly bind transcription factors and be regulated by a diffusible extracellular substance: Wnt. It acts upon early embryos to induce entire body regions, as well as individual cells in later stages of development. It also regulates physiological regeneration processes. Wnt signaling and beta-catenin dependent gene expression plays a critical role during the formation of different body regions in the early embryo.
• 产品名称Anti-Beta-catenin antibody [10-C0-B7]
• 分子量85kDa
• 种属反应性Human,Mouse,Rat
• 验证应用WB,ICC,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2b
• 纯化方式Protein G purified.
• 亚细胞定位Cytoplasm, nucleus
• 其它名称
  • Beta catenin antibody
  • Beta-catenin antibody
  • Cadherin associated protein antibody
  more

• 应用

  WB: 1:2000
  ICC: 1:200

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  Fig1: Western blot analysis on 293T cell lysates using anti- Beta-catenin mouse mAb.

   

  

  Fig2: ICC staining Beta-catenin in Hela cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).

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