Anti-AKR7A2 antibody [C10-D5]
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概述
- 产品描述Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene. It catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate and may have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). AKR7A2 has broad substrate specificity and NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2 can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro) and reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It may be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
- 产品名称Anti-AKR7A2 antibody [C10-D5]
- 分子量40 kDa
- 种属反应性Human,Zebrafish
- 验证应用WB,ICC,IHC-P
- 抗体类型小鼠单抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG1
- 纯化方式Protein A purified.
- 亚细胞定位Cytoplasm, Golgi apparatus
- 其它名称
- AFAR antibody
- AFAR1 antibody
- AFB1 aldehyde reductase 1 antibody
more
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应用
WB: 1:1,000-1:2,000
ICC: 1:200
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Fig1: Western blot analysis of AKR7A2 on human spermatozoa lysate using anti-AKR7A2 antibody at 1/1,000 dilution.
Fig2: ICC staining AKR7A2 in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Western blot analysis of AKR7A2 on hybrid fish (crucian-carp) liver tissue lysate using anti-AKR7A2 antibody at 1/1,000 dilution.
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