Anti-PAX3 antibody [G7-D8]

Anti-PAX3 antibody [G7-D8]

• 概述

• 产品描述Pax genes contain paired domains that share strong homology to genes in Drosophila which are involved in programming early development. The product of the Pax-3 gene is a DNA-binding protein expressed during early neurogenesis. Pax-3 is a protein containing both a paired domain and a paired-type homeodomain. During early neurogenesis, Pax-3 expression is limited to mitotic cells in the ventricular zone of the developing spinal cord and to distinct regions in the hindbrain, midbrain and diencephalon. In 10-12 day embryos, expression of Pax-3 is also seen in neural crest cells of the developing spinal ganglia, the craniofacial mesectoderm and in limb mesenchyme. Mutations in the MITF and Pax-3 genes, encoding transcriptions factors, are responsible for Waardenburg syndrome II (WS2) and WS1/WS3, respectively. Pax-7 is a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization revealed that Pax-7 is also expressed in satellite cells residing in adult muscle. The gene which encodes Pax-7 maps to human chromosome 1p36.2-p36.12.
• 产品名称Anti-PAX3 antibody [G7-D8]
• 分子量53 kDa
• 种属反应性Human,Mouse
• 验证应用WB
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Nucleus.
• 其它名称
  • CDHS antibody
  • HUP 2 antibody
  • HUP2 antibody
  more

• 应用

  WB: 1:500-1:1,000

•  

  

  Fig1: Western blot analysis of PAX3 on human PAX3 recombinant protein using anti-PAX3 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of PAX3 on HEK293 (1) and PAX3-hIgGFc transfected HEK293 (2) cell lysate using anti-PAX3 antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of PAX3 on different cell lysate using anti-PAX3 antibody at 1/1,000 dilution.
  Positive control:
  Line1:Mouse brain Line2:Rat spleen Line3:Mouse liver

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