Anti-S100 beta antibody
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概述
- 产品描述The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100 ? and ∫, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin ? and parvalbumin ∫ (also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 ? chain and S-100 ∫ chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two ? chains, two ∫ chains or one ? and one ∫ chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 ? and ∫ are present in a variety of other tissues, and calbindin is present in intestine and kidney.
- 产品名称Anti-S100 beta antibody
- 分子量21kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IP,IF
- 抗体类型兔多抗
- 免疫原Amino acids 37-92 mapping at the C-terminus of S-100 β chain of human origin.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cytoplasm, Nucleus
- 其它名称
- NEF antibody
- Protein S100 B antibody
- Protein S100-B antibody
more
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应用
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
IF: 1:50-1:500
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Fig1: Western blot analysis of S-100 β chain expression in C6 whole cell lysate.
Fig2: Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
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