Anti-CD95 / Fas antibody
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概述
- 产品描述Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.
- 产品名称Anti-CD95 / Fas antibody
- 分子量48 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IHC-P,ICC,IP
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Membrane
- 其它名称
- ALPS1A antibody
- APO 1 antibody
- APO 1 cell surface antigen antibody
more
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应用
WB: 1:1,000
ICC: 1:50-500
IHC-P: 1:50-500
IP: 1-2 μg per 100-500 μg of total protein
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Fig1: A. Western blot analysis of FAS expression in rat thymus tissue extract.
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