Anti-UBN-1 antibody
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概述
- 产品描述Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Belongs to the ubinuclein family. subcellular location:Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis. subunit:Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3. 3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3. tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
- 产品名称Anti-UBN-1 antibody
- 种属反应性Human,Mouse
- 验证应用WB,IHC-P,IF
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- UBN1 antibody; Ubinuclein-1 antibody; HIRA-binding protein antibody; Protein VT4 antibody; Ubiquitously expressed nuclear protein antibody;
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应用
IHC-P: 1:100-1:300
IF: 1:100-1:500
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
