Anti-SOCS-1 antibody
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概述
- 产品描述This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
- 产品名称Anti-SOCS-1 antibody
- 分子量38 kDa
- 种属反应性Human, Mouse, Rat
- 验证应用IF, WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human SOCS-1. AA range:49-98
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- SOCS1 antibody; SSI1 antibody; TIP3 antibody; Suppressor of cytokine signaling 1 antibody; SOCS-1 antibody; JAK-binding protein antibody; JAB antibody; STAT-induced STAT inhibitor 1 antibody; SSI-1 antibody; Tec-interacting protein 3 antibody; TIP-3 antibody;
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应用
IF: 1:50-200 WB: 1:500-1:2000
IHC-P: 1:50-300
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Fig1: Immunofluorescence analysis of mouse-liver tissue. 1,SOCS-1 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B
Fig2: Immunohistochemical analysis of paraffin-embedded Human-uterus tissue. 1,SOCS-1 Polyclonal Antibody was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min). Negative control was used by secondary antibody only.
Fig3: Western Blot analysis of various cells using SOCS-1 Polyclonal Antibody diluted at 1：2000
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
