Anti-Rag A/B antibody
-
概述
- 产品描述Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14. 7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Belongs to the GTR/RAG GTP-binding protein family. subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14. 7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. subunit:Can occur as a homodimer, or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14. 7 kDa protein. tissue specificity:Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
- 产品名称Anti-Rag A/B antibody
- 分子量34 kDa
- 种属反应性Human, Mouse, Rat
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human RRAGA/B. AA range:264-313
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称
- RRAGA antibody; Ras-related GTP-binding protein A antibody; Rag A antibody; RagA antibody; Adenovirus E3 14.7 kDa-interacting protein 1 antibody; FIP-1 antibody; RRAGB antibody; Ras-related GTP-binding protein B antibody; Rag B antibody; RagB antibody;
-
应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
-
Fig1: Western Blot analysis of various cells using Rag A/B Polyclonal Antibody diluted at 1：1000
Fig2: Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4°,overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
