Anti-HM74 antibody
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概述
- 产品描述developmental stage:Expression in neutrophils occurs in the late terminal differentiation phase. Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. miscellaneous:The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Belongs to the G-protein coupled receptor 1 family. tissue specificity:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
- 产品名称Anti-HM74 antibody
- 分子量45 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IF
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human GPR109. AA range:285-334
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称HCAR3 antibody; GPR109B antibody; HCA3 antibody; HM74B antibody; NIACR2 antibody; Hydroxycarboxylic acid receptor 3 antibody; G-protein coupled receptor 109B antibody; G-protein coupled receptor HM74 antibody; G-protein coupled receptor HM74B antibody; Niacin receptor 2 antibody; Nicotinic acid receptor 2 antibody; HCAR2 antibody; GPR109A antibody; HCA2 antibody; antibody;
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应用
WB: 1:500-1:2000
IF: 1:100-1:500
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
