Anti-Endophilin I antibody
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概述
- 产品描述domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface. Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. miscellaneous:HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation. Belongs to the endophilin family. Contains 1 BAR domain. Contains 1 SH3 domain. subcellular location:Concentrated in presynaptic nerve terminals in neurons. subunit:Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP. tissue specificity:Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
- 产品名称Anti-Endophilin I antibody
- 分子量39 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB
- 抗体类型兔多抗
- 免疫原Synthesized peptide derived from Endophilin I . at AA range: 30-110
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称SH3GL2 antibody; CNSA2 antibody; SH3D2A antibody; Endophilin-A1 antibody; EEN-B1 antibody; Endophilin-1 antibody; SH3 domain protein 2A antibody; SH3 domain-containing GRB2-like protein 2 antibody;
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