Anti-HURP antibody
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概述
- 产品描述developmental stage:Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells. PTM:Ubiquitinated, leading to its degradation. Belongs to the SAPAP family. subcellular location:Localizes to the spindle poles in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells. subunit:Interacts with CDC2. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Interacts with CDH1. tissue specificity:Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
- 产品名称Anti-HURP antibody
- 分子量95 kDa
- 种属反应性Human
- 验证应用WB
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human DLGAP5. AA range:791-840
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称DLGAP5 antibody; DLG7 antibody; KIAA0008 antibody; Disks large-associated protein 5 antibody; DAP-5 antibody; Discs large homolog 7 antibody; Disks large-associated protein DLG7 antibody; Hepatoma up-regulated protein antibody; HURP antibody;
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Fig1: Western Blot analysis of various cells using HURP Polyclonal Antibody
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